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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>BQU57
BQU57
  • BQU57

BQU57 NEW

Price $34 $56 $98
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: BQU57 CAS No.: 1637739-82-2
Purity: 98.59% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameBQU57
DescriptionBQU57 selectively inhibits Ral over Ras or Rho and suppresses xenograft tumor growth.
Cell ResearchGrowth inhibition on human lung cancer cells by the compounds are measured under anchorage-independent conditions in soft agar. Cells are seeded into 6-well plates (coated with a base layer made of 2.0 mL of 1% low-melting-point agarose) at 15,000 cells per well in 3.0 mL of 0.4% low-melting-point agarose containing various concentration of drug. Two to four weeks (depending on cell line) after incubation, cells are stained with 1.0 mg/mL Nitro Blue Tetrazolium and colonies are counted under a microscope. The IC50 values are defined as the concentration of drug that resulted in 50% reduction in colony number compared to DMSO treated control. After 48 hr, cells are subjected to the soft agar colony formation assay. (Only for Reference)
Kinase AssayHDAC Enzyme Assay: The commercially availablae human recombinant enzyme and fluorogenic HDAC assay kits have used to measure percent inhibition and IC50 values of three HDAC isozymes (HDAC2, HDAC4, HDAC6). Briefly, the inhibitor is added sequentially to a black, flat-bottom 96-well microtiter plate, and the reaction mixture is incubated for 30 min at 37°C. The potent HDAC inhibitor trichostatin A (included in the assay kit) is added to the bifunctional HDAC assay developer at a final reaction concentration of 1 μM to stop deacetylation and initiate the release of the fluorophore. The reaction mixture is further incubated at room temperature for 15 min. Fluorescence is measured on a Spectra Max Gemini XPS using an excitation wavelength of 360 nm and a detection wavelength of 460 nm.
In vitroBQU57 inhibited RalA and RalB activation in H2122 and H358 cell lines, resulting in cell growth inhibition.
In vivoBQU57 inhibited RalA and RalB activation in H2122 and H358 cell lines, resulting in cell growth inhibition.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.98 mM), Sonication is recommended.
Ethanol : 16 mg/mL (47.86 mM), Sonication is recommended.
DMSO : 40 mg/mL (119.65 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
KeywordsRas | Inhibitor | inhibit | GTPase Ral | BQU-57 | BQU57 | BQU 57
Inhibitors RelatedAdagrasib | BI-2493 | Exo-1 | RMC-9805 | (R)-Naproxen | Ketoconazole | MRTX1133 | Sotorasib | RMC-7977 | Daraxonrasib | AMG410 | NMac1
Related Compound LibrariesAnti-Colorectal Cancer Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Prostate Cancer Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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