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• Ivabradine related compound 12(Hydrochloride)

• Product Information

• Product Code: I002012A

• English Name: Ivabradine related compound 12(Hydrochloride)

• English Alias: (R)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine hydrochloride

• CAS No.：1204612-29-2

• Molecular Formula: C??H??NO?·HCl

• Molecular Weight: 243.73 (207.27 + 36.46)

• Advantages

• Structural Confirmation: Characterized by NMR, HRMS, and HPLC (≥98.5%) for reliable identification.

• Stability: Stable for 18 months at 2-8℃, with <1% degradation in methanol-HCl solution.

• Regulatory Compliance: Supports ICH Q3A/B guidelines for impurity profiling.

• Applications

• Quality Assurance: Used in HPLC/LC-MS for impurity detection in Ivabradine formulations, ensuring compliance with pharmacopoeia.

• Synthesis Monitoring: Tracks amine hydrochloride formation during Ivabradine synthesis to optimize purification steps.

• Analytical Method Validation: Validates specificity and linearity of detection methods.

• Background Description

• This impurity originates from incomplete cyclization or amine substitution in Ivabradine synthesis, a cardiac pacemaker inhibitor. Controlling such impurities is critical for maintaining drug efficacy and safety.

• Research Status

• Detection: HPLC with reversed-phase column (C18, 5μm) and phosphate buffer-acetonitrile elution; LOD: 0.05 μg/mL.

• Formation Mechanism: Results from side reactions of dimethoxycycloalkene intermediates; optimized base catalysis reduces generation by 50%.

• Safety Evaluation: In vitro cardiotoxicity tests show no significant effects at therapeutic concentrations; further toxicology studies pending

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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