Product Details
| Product Name:
BTM-1086 |
CAS No.:
72293-17-5 |
| Supply Ability:
10g |
Release date:
2025/08/01 |
Product Introduction
Bioactivity
| Name | BTM-1086 |
| Description | BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent. |
| In vitro | BTM-1086 has a high affinity (pKi: 8.31-9.15) for the three muscarinic receptor subtypes in the guinea-pig cortex (M1), heart (M2), and salivary glands (M3) [1]. |
| In vivo | BTM-1086 (0.1 to 1 mg/kg, p.o.) prevents the development of ulcers, but only weakly inhibits the histamine-induced gastric ulcer. The inhibitory activities of BTM-1086 are significantly higher than those of atropine sulfate. In the healing experiment with the acetic acid-induced stomach ulcer, BTM-1086 (1 mg/kg/day, p.o., x14) shows a significant healing effect, which is higher than that of propantheline bromide. BTM-1086 (0.2 mg/kg, i.d.) remarkably inhibit the gastric secretion 6 hr after pylorus ligation. The aspirin-induced reductions of the total acid and K+ as well as the increments of the volume and Na+ in the gastric secretion are prevented dose-dependently by pretreatment with BTM-1086. The LD50 value by oral, s.c., and i.v. administration with BTM-1086 is 880, 630, and 113 mg/kg, respectively, for male rats and 830, 650, and 119 mg/kg, respectively, for female rats [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Muscarinic receptor | BTM-1086 | BTM1086 | BTM 1086 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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