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Postion:Product Catalog >BTYNB
BTYNB
  • BTYNB

BTYNB NEW

Price $57 $94 $138
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: BTYNB CAS No.: 304456-62-0
Purity: 99.91% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameBTYNB
DescriptionBTYNB (MDK6620)?is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA).?MDK6620?downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB).?It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
In vitroIn cells, BTYNB downregulates several mRNA transcripts regulated by IMP1.?BTYNB destabilizes c-Myc mRNA, resulting in downregulation of c-Myc mRNA and protein.?BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB).?The oncogenic translation regulator, eEF2, emerged as a new IMP1 target mRNA, enabling BTYNB to inhibit tumor cell protein synthesis.?BTYNB potently inhibited proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.?Overexpression of IMP1 reversed BTYNB inhibition of cell proliferation.?BTYNB completely blocked anchorage-independent growth of melanoma and ovarian cancer cells in colony formation assays.?With its ability to target c-Myc and to inhibit proliferation of difficult-to-target melanomas and ovarian cancer cells, and with its unique mode of action, BTYNB is a promising small molecule for further therapeutic evaluation and mechanistic studies[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.47 mM), Sonication is recommended.
DMSO : 70 mg/mL (226.41 mM), Sonication is recommended.
Ethanol : 4 mg/mL (12.94 mM), Sonication is recommended.
KeywordsSK-MEL2 | NF-κB | NFκB | NF-kB | NFkB | MDK-6620 | MDK 6620 | IMP1 | IGROV-1 | ES-2 | c-Myc | cMyc | cancer cell | BTYNB
Inhibitors RelatedUndecane | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Fumaric acid | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | D-Psicose | N,N-Dimethylacetamide | Magnesium sulfate
Related Compound LibrariesAnti-Lung Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Antioxidant Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Liver Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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