Product Details
| Product Name:
Bufalin |
CAS No.:
465-21-4 |
| Purity:
99.80% |
Supply Ability:
10g |
| Release date:
2026/05/15 |
Product Introduction
Bioactivity
| Name | Bufalin |
| Description | Bufalin is a natural product and a Na?/K?-ATPase inhibitor (IC50 ≈ 40–45 nM) with favorable cell permeability. By binding to α subunits such as ATP1A1, bufalin induces calcium overload and pyroptosis, and can be used for experimental research and therapeutic exploration in various cancers. |
| In vitro | Methods: Human lung cancer cells A549 and H1299 were incubated with 40 ng/ml Bufalin for 24 hours.
Results: Bufalin significantly inhibited cell viability, colony formation, and soft agar colony formation in a concentration-dependent manner.[1]
Methods: Human colon cancer HCT-116 and SW620 cells were incubated with gradient concentrations of Bufalin for 48 hours, respectively.
Results: Bufalin inhibited cell proliferation in a concentration-dependent manner, with IC?? values of 12.823±1.792 nM and 26.303±2.498 nM, respectively.[2] |
| In vivo | Methods: A549 or H1299 cells were inoculated into nude mice. When tumor volume reached 220–250 mm3, Bufalin 1 mg/kg was administered by subcutaneous or intraperitoneal injection daily or every other day (with DMSO as the vehicle) for 25 consecutive days.
Results: Tumor volume and weight in the Bufalin group were significantly lower than those in the control group. [1] |
| Storage | Keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (10.35 mM), Sonication is recommended.
DMSO : 100 mg/mL (258.72 mM), Sonication is recommended.
|
| Keywords | Sodium potassium pump | Na+/K+-ATPase | Na+/K+ ATPase | Inhibitor | inhibit | Bufalin |
| Inhibitors Related | Tirofiban hydrochloride monohydrate | Sodium oleate | Permethrin | Tolbutamide | trans-Aconitic acid | Phlorizin | Chlorpropamide | 2,3-Butanedione 2-Monoxime | Revaprazan hydrochloride | Oleic acid | Cyclocreatine | Esomeprazole Sodium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Membrane Protein-targeted Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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