Bumetanide sodium NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Bumetanide sodium | CAS No.: 28434-74-4 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Bumetanide sodium |
| Description | Bumetanide sodium is a potent loop diuretic that acts as a blocker for the sodium-potassium-chloride cotransporter (NKCC). It selectively inhibits NKCC1 and NKCC2, with IC50 values of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] [2]. |
| In vitro | Bumetanide sodium effectively inhibits the major human splice variants of NKCCs, specifically hNKCC1A and hNKCC2A. It demonstrates dose-dependent inhibition of ^86Rb^+ uptake in NKCC1A-expressing oocytes, ranging from 0.03 to 100 μM over 5 minutes. Additionally, Bumetanide sodium targets the NKCC2 isoform B in HEK-293 cells, achieving an IC50 value of 0.54 μM. |
| In vivo | Bumetanide sodium (7.6-30.4 mg/kg; i.v.) reduces the decline in apparent diffusion coefficients (ADC) ratios in the cortex and striatum by 40-67%, indicating decreased edema formation [3], and decreases infarct size [3]. It has varying half-lives—21.4 min, 53.8 min, and 137 min—after intravenous doses of 2 mg/kg, 8 mg/kg, and 20 mg/kg, respectively, in rats [4]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Furosemide-D5 | Bumetanide (Standard) | KCC2 potentiators-1 | Sodium dichloroacetate | Carbonic anhydrase inhibitor 32 | Piretanide | Furosemide | Furosemide sodium | Azosemide | ZT-1a | Bumetanide | Torsemide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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