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Postion:Product Catalog >BVT948
BVT948
  • BVT948

BVT948 NEW

Price $73 $106 $159
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: BVT948 CAS No.: 39674-97-0
Purity: 98.87% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameBVT948
DescriptionBVT948 is a protein tyrosine phosphatase (PTP) inhibitor that also inhibits lysine methyltransferase SETD8 (KMT5A) and various cytochrome P450 (P450) isoforms.
In vitroBVT948 exhibits dose-dependent inhibition of TPA-induced MMP-9 up-regulation, without affecting MAPK phosphorylation caused by TPA. It reduces TPA-induced cell invasion by 50%. Interestingly, BVT948 does not significantly alter cell viability in MCF-7 cells at concentrations of 0.5, 1, or 5 μM over 24 hours. Furthermore, BVT948 is a potent inhibitor of protein tyrosine phosphatases (PTP) and P450 activities, demonstrating its ability to selectively suppress H4 lysine 20 (H4K20me1) methylation at doses below 5 μM within 24 hours. Additionally, it enhances the insulin signal's strength without affecting its duration and induces cell-cycle-arrest phenotypes reminiscent of those observed with SETD8 knockdown via RNAi. BVT948 also effectively inhibits TPA-induced NF-κB binding activity but not AP-1 binding activity, showcasing its selective inhibitory properties on specific molecular targets.
In vivoCompare with vehicle-treated controls, BVT948 (BVT.948, 3 μmol/kg) significantly enhances glucose clearance from the blood stream in response to insulin[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (16.58 mM), Sonication is recommended.
DMSO : 100 mg/mL (414.52 mM), Sonication is recommended.
KeywordsSETD8 | PTP | protein tyrosine phosphatase(PTP) | Phosphatase | P450 | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | Cytochrome P450 | CYPs | BVT-948 | BVT948 | BVT 948
Inhibitors RelatedOxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Hexane-1,6-diol | Sudan IV | Stearic acid | Naringin | L-Ascorbic acid 2-phosphate magnesium | Dibenzothiophene | Clarithromycin
Related Compound LibrariesReprogramming Compound Library | Methylation Compound Library | Histone Modification Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | ReFRAME Related Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$73.00
VIP6Y
TargetMol Chemicals Inc.
2026-05-11

TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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