Bz 423 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Bz 423 | CAS No.: 216691-95-1 |
| Purity: 98.89% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Bz 423 |
| Description | Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus. |
| In vitro | Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.48 mM), Sonication is recommended. DMSO : 80 mg/mL (181.44 mM), Sonication is recommended. |
| Keywords | BZ-48 | BZ 48 | Bz 423 | Bax | Bak | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:326802-62-4
-
CAS:4005-49-6
-
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
|
VIP2Y
|
Shenzhen Nexcon Pharmatechs Ltd.
|
2026-06-18 | ||
| $35.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
|
VIP5Y
|
Zhejiang J&C Biological Technology Co.,Limited
|
2025-12-25 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY