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Postion:Product Catalog >c-Kit-IN-3
c-Kit-IN-3
  • c-Kit-IN-3

c-Kit-IN-3 NEW

Price $79 $165 $267
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-04-20

Product Details

Product Name: c-Kit-IN-3 CAS No.: 2363169-01-9
Purity: 99.94% Supply Ability: 10g
Release date: 2026/04/20

Product Introduction

Bioactivity

Namec-Kit-IN-3
Descriptionc-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).
In vitroIn primary GIST patient cells, c-Kit-IN-3 (0.1-10 μM) exhibits dose-dependent antiproliferative effects. In GIST-T1, GIST-T1-T670I, and GIST-5R cells, c-Kit-IN-3 (0.01-1 μM) induces dose-dependent cell apoptotic death and arrests the cell cycle into the G0/G1 phase[1].
In vivoc-Kit-IN-3 (1 mg/kg i.v. for mice, rats, dog; 10 mg/kg p.o. for mice, rats; 5 mg/kg p.o. for dog) has T1/2 of 4.5 h, 6.4 h, 19.4 h for mice, rats and dogs, respectively. c-Kit-IN-3 possesses acceptable bioavailability of 43%, 50% and 81% for mice, rats, and dogs. In female BALB/C-nu mice, c-Kit-IN-3 (20-100 mg/kg; gavage) treatment dose-dependently inhibits the tumor progression[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 100 mg/mL (193.46 mM), Sonication is recommended.
Keywordsc-Kit-IN-3 | cKitIN3 | c-KIT w | c-KIT T670I | c-Kit | cKit | c Kit IN 3
Inhibitors RelatedGilteritinib | Regorafenib monohydrate | Sunitinib | Toceranib Phosphate | Sorafenib | Dasatinib | Pexidartinib | Regorafenib | Lenvatinib mesylate | Dasatinib monohydrate | Lenvatinib | Pazopanib
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Hematonosis Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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