Product Details
| Product Name:
C004019 |
CAS No.:
2417159-57-8 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2026/05/15 |
Product Introduction
Bioactivity
| Name | C004019 |
| Description | C004019 belongs to PROTACs and is a tau protein-targeted degrader (via recruitment of VHL E3 ligase) with blood-brain barrier permeability and selective tau degradation capability. This compound significantly reduces tau levels and improves cognitive function, and is used in research on Alzheimer's disease and related tauopathies. |
| In vitro | Methods: HEK293 cells stably expressing full-length human tau protein (HEK293-hTau) and SH-SY5Y cells were treated with C004019 for 24 h, and cell viability and tau protein expression levels were detected, respectively.
Results: Within the concentration range of 0.01–100 μM, C004019 had no significant effect on HEK293-hTau cell viability; at concentrations of 0.01–20 μM, C004019 inhibited total tau and phosphorylated tau protein expression.[1] |
| In vivo | Methods: To evaluate the clearance of brain tau protein and effects on cognitive function by C004019, different administration Methods were employed in wild-type, 3xTg-AD, and hTau mouse models: single intracerebroventricular injection of C004019 (5 μL, 200 μM); single subcutaneous injection (3-15 mg/kg); and long-term subcutaneous injection (3 mg/kg, once every 6 days for a total of 5 times), with detection of brain tau protein levels, cognitive function, and synaptic function changes.
Results: Intracerebroventricular administration of C004019 reduced brain tau protein levels in wild-type and 3xTg-AD mice; single subcutaneous injection effectively cleared brain tau protein in wild-type mice; long-term subcutaneous injection promoted brain tau protein clearance in hTau and 3xTg-AD mice and improved their cognitive and synaptic function.[1] |
| Storage | Keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 255 mg/mL (246.31 mM)
|
| Keywords | tau | PROTAC | MicrotubuleAssociated | Microtubule Associated | C-004019 | C004019 | C 004019 |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Pregnenolone acetate | Oxfendazole | α-Cyclodextrin | Methylene Blue trihydrate | Vepdegestrant | Paclitaxel | 4'-Demethylepipodophyllotoxin | Albendazole |
| Related Compound Libraries | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States