C12-200 NEW
| Price | $32 | $73 | $123 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-19 |
Product Details
| Product Name: C12-200 | CAS No.: 1220890-25-4 |
| Purity: 99.68% | Supply Ability: 10g |
| Release date: 2026/05/19 |
Product Introduction
Bioactivity
| Name | C12-200 |
| Description | C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations. |
| In vitro | Methods: After intraperitoneal injection of siRNA-Cy5.5 (C12-200) LNPs (1 mg/kg) in mice, peritoneal lavage fluid was collected at 6 and 24 hours to analyze Cy5.5 signal in F4/80?? CD11b?? macrophages (LPMs). Results: At both 6h and 24h, the mean fluorescence intensity of Cy5.5 and the percentage of Cy5.5? cells in LPMs were significantly elevated. [1] |
| In vivo | Methods: Acute liver injury was induced in mice by intraperitoneal injection of APAP (300 mg/kg). Six hours later, siRNA-Cy5 (C12-200) LNPs (1 mg/kg siRNA) were administered via intraperitoneal injection. Results: It was demonstrated that GLPMs enter the bloodstream following liver injury and were successfully labeled by C12-200 LNP. [2] |
| Storage | Keep away from moisture,Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (79.16 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (2.9 mM), Sonication is recommended. |
| Keywords | C-12-200 | C12200 | C12 200 |
| Inhibitors Related | Stearamide | DOPE | DOTAP chloride | Dimethyldioctadecylammonium (bromide) | DMG-PEG 2000 | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine | DODAP | D-Lin-MC3-DMA | Benzyl nicotinate | 1,2-Dierucoyl-sn-glycero-3-PC | Cholesterol | Phosphatidylcholines,soya |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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