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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Microbiology>Integrase Inhibitors>Cabotegravir
Cabotegravir
  • Cabotegravir

Cabotegravir NEW

Price $46 $89 $158
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-04-20

Product Details

Product Name: Cabotegravir CAS No.: 1051375-10-0
Purity: 99.92% Supply Ability: 10g
Release date: 2026/04/20

Product Introduction

Bioactivity

NameCabotegravir
DescriptionCabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Kinase AssayIn vitro strand transfer assay: The inhibitory concentrations of GSK1265744 is measured in a strand transfer assay using recombinant HIV IN. A complex of integrase and biotinylated donor DNA–streptavidin-coated SPA beads is formed by incubating 2 μM purified recombinant integrase with 0.66 μM biotinylated donor DNA–4 mg/mL streptavidin-coated SPA beads in 25 mM sodium MOPS pH 7.2, 23 mM NaCl, and 10 mM MgCl2 for 5 minutes at 37°C. These beads are spun down and preincubated with diluted INSTIs for 60 minutes at 37°C. Next, [3H]-labeled target DNA substrate is added to give a final concentration of 7 nM substrate, and the strand transfer reaction is incubated at 37°C for 25 to 45 minutes, which allowed for a linear increase in strand transfer of donor DNA to radiolabeled target DNA. The signal is read using a Wallac MicroBeta scintillation plate reader.
In vivoGSK1265744 (50 mg/kg) effectively prevents high-dose SHIV infection in rhesus macaques.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 16.67 mg/mL (41.12 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
KeywordsUGT1A1 | S/GSK-1265744 | S/GSK 1265744 | OAT | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV Integrase | HIV | GSK-744 | GSK1265744 | GSK 744 | GSK 1265744 | Cabotegravir | antiretroviral | AIDS
Inhibitors RelatedStavudine | 5-Fluorouracil | Emtricitabine | Dolutegravir intermediate-1 | Dimethyl fumarate | Lamivudine | Chloroquine phosphate | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Tenofovir
Related Compound LibrariesFDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Pediatric Drug Library | Drug-induced Liver Injury (DILI) Compound Library | EMA Approved Drug Library | Toxic Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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