CAL-130 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: CAL-130 | CAS No.: 1431697-74-3 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | CAL-130 |
| Description | CAL-130 is a PI3Kδ and PI3Kγ inhibitor [IC50s: 1.3 and 6.1 nM]. |
| In vitro | CAL-130 selectively inhibits the catalytic domains of p110γ and p110δ (IC50s: 1.3 and 6.1 nM for p110δ and p110γ, 115 and 56 nM for p110α and p110β) without affecting other intracellular signaling pathways such as p38 MAPK or insulin receptor tyrosine kinase, which are essential for overall cell function and survival. |
| In vivo | The clinical impact of inhibiting both PI3Kγ and PI3Kδ activities is assessed through the administration of CAL-130 to Lck/Pten^fl/fl mice suffering from established T cell acute lymphoblastic leukemia. Selection of mice for the survival study is based on criteria including poor health appearance, a white blood cell count exceeding 45,000/μL, presence of blast cells in peripheral blood smear, and over 75% of circulating cells being double-positive for Thy1.2 and Ki-67 markers. These mice are then treated with an oral dosage (10 mg/kg) of CAL-130 every eight hours for a week, and their health outcomes are monitored until they become moribund. Despite the short treatment period, CAL-130 significantly increases the median survival rate of these mice to 45 days, in stark contrast to the 7.5 days survival of the control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | p110δ | p110γ | p110β | p110α | CAL-130 | CAL130 | CAL 130 |
| Inhibitors Related | Myricetin | Erucic acid | Sapanisertib | (2S,3R,4S)-4-Hydroxyisoleucine | 3-Methyladenine | Duvelisib (R enantiomer) hydrochloride | RLY-2608 | Isoprenaline hydrochloride | Quercetin Dihydrate | Apilimod | LY294002 | Idelalisib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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