Calhex 231 hydrochloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Calhex 231 hydrochloride | CAS No.: 2387505-78-2 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Calhex 231 hydrochloride |
| Description | Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock. |
| In vitro | Methods: LX-2 cells were treated with Calhex 231 hydrochloride (2.5, 5, 7.5, 10 μM, 48 hours), and cell viability was detected by MTT assay. Results: Calhex 231 hydrochloride could inhibit the growth of LX-2 cells, with an IC50 value of 9.5 μM. [4] |
| In vivo | Methods: Transverse aortic constriction (TAC) induced pressure overload and cardiac hypertrophy in male Wistar rats. Four weeks after TAC, rats were treated with Calhex 231 hydrochloride (10 μmol/kg, 4 weeks) for 4 weeks and analyzed 12 weeks after surgery. Rats were sacrificed and hearts were rapidly excised and weighed in cold (4 °C) buffer. The left and right ventricles were then isolated and weighed, and the left ventricular tissue was snap-frozen in liquid nitrogen and stored at -80 °C for subsequent western blot analysis. Results: Animals were observed to exhibit increases in interventricular septum (IVS) thickness, left ventricular posterior wall (LVPW) thickness, left ventricular internal dimension (LVID), left ventricular diastolic volume (LVDV), and left ventricular systolic volume (LVSV), as well as decreases in left ventricular fractional shortening (LVFS) and left ventricular ejection fraction (LVEF). [5] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | CaSR | Calhex 231 Hydrochloride |
| Inhibitors Related | Ciprofloxacin hydrochloride monohydrate | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Permethrin | Ciprofloxacin monohydrochloride | Strontium chloride | (-)-Epigallocatechin Gallate | Phosphocreatine disodium | Sodium Molybdate | 4-Pentenoic acid | L-Histidine |
| Related Compound Libraries | Cuproptosis Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Multi-Target Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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