Candesartan NEW
| Price | $54 | $118 | $177 |
| Package | 10mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: Candesartan | CAS No.: 139481-59-7 |
| Purity: 96.10% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | Candesartan |
| Description | Candesartan (CV 11974) is an angiotensin II receptor blocker widely used in the treatment of hypertension and heart failure. |
| Cell Research | KU-19-19 cells are seeded at a cell density of 2 × 104 per well in 96-well plates and allowed to grow overnight. Then the cells are treated with various concentrations of Candesartan for various periods of time. Cell viability is determined by the Alamar Blue assay to examine the cytotoxicity and antiproliferative effect of candesartan. The absorbance value of each well is determined in a microplate reade(Only for Reference) |
| Kinase Assay | Binding assay: Cells are plated in 24-well plates and cultured until confluence. Before the experiment, the cells are washed three times with 0.5 mL per well of DMEM at room temperature. After removal of the medium, 400 μL binding DMEM is added and the plate is then left for 15 min at 37 ℃. For saturation binding assays cells are incubated with increasing concentrations [3H]Candesartan (final concentrations between 0.15 nM and 15 nM) in a final volume of 0.5 mL at 37 ℃ for 5 min to 180 min. For competition binding assays 50 μL of buffer or 50 μL of buffer containing increasing concentrations of unlabelled Candesartan is added. After 30 min, 50 μL of buffer containing [3H]Candesartan (final concentration 1.1 nM) or [3H]Candesartan (final concentration 1.0 nM) is added, and the cells are further incubated for 30 min at 37 ℃. |
| In vitro | In mice carrying KU-19-19 xenografts, Candesartan (10 mg/kg) reduced microvascular density and VEGF expression, inhibiting tumor cell growth. In WKY rats, a lower dose of Candesartan (0.5 mg/kg) decreased blood pressure and inhibited the binding of AT1 in various brain regions, including the subfornical organ, paraventricular nucleus of the hypothalamus, solitary tract nucleus, and the area postrema. Furthermore, in adult spontaneously hypertensive rats, Candesartan (0.3 mg/kg) reduced the infarct size, diminished severe ischemic lesions in the peri-infarct and subcortical areas, and lessened the decrease in cerebral blood flow. |
| In vivo | In CHO-AT1 cells, Candesartan binds with high selectivity to the angiotensin II AT1 receptors. At a concentration of 0.1 nM, Candesartan can reduce the maximum constrictive response to angiotensin II. Additionally, in KU-19-19 cells, the introduction of Candesartan leads to an upregulation of VEGF and interleukin-8 expression, without affecting cell proliferation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.27 mM), Sonication is recommended. DMSO : 4.5 mg/mL (10.22 mM), Sonication is recommended. |
| Keywords | Traumatic brain injury (TBI) | PPAR-γ | oral | Inhibitor | inhibit | hypertension | hronic heart failure (CHF) | CV-11974 | CV11974 | Candesartan | AT1 receptor | antihypertensive | Angiotensin Receptor | angiotensin II AT1-Receptor |
| Inhibitors Related | PHYTOL | Losartan potassium | Rosiglitazone | Daidzein | Magnesium acetate tetrahydrate | Sacubitril/Valsartan | Maltitol | 2,3-Butanediol | NPC 15199 | Diisononyl phthalate | Captopril | Cloxiquine |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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