CAY10763 NEW
| Price | $548 | $2130 |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-14 |
Product Details
| Product Name: CAY10763 | CAS No.: 2364458-49-9 |
| Supply Ability: 10g | Release date: 2026/04/14 |
Product Introduction
Bioactivity
| Name | CAY10763 |
| Description | CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : 30 mg/mL (63.62 mM), Sonication is recommended. DMSO : 30 mg/mL (63.62 mM), Sonication is recommended. Ethanol : 30 mg/mL (63.62 mM), Sonication is recommended. |
| Keywords | CAY-10763 | CAY 10763 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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