Product Details
| Product Name:
CC-90005 |
CAS No.:
1799574-70-1 |
| Supply Ability:
10g |
Release date:
2026/06/05 |
Product Introduction
Bioactivity
| Name | CC-90005 |
| Description | CC-90005 is a potent, selective, and orally active inhibitor of protein kinase C-θ (PKC-θ) with an IC50 of 8 nM, demonstrating strong selectivity over PKC-δ (IC50=4440 nM). Additionally, CC-90005 can inhibit T cell activation by IL-2 expression[1]. |
| In vitro | CC-90005 exhibits high selectivity with IC50 values for all other family members exceeding 3 μM. It is a moderate inhibitor of CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes. CC-90005 inhibits IL-2 expression in LRS_WBC human PBMCs with an IC50 of 0.15 μM. Additionally, CC-90005 (1-10 μM; 24 h) inhibits T cell proliferation in PBMCs by 51% at 1 μM and 88% at 3 μM[1]. |
| In vivo | CC-90005 (3-30 mg/kg; p.o. twice daily for 4 days) significantly reduces the popliteal lymph node (PLN) size in a model of chronic T cell activation[1]. Additionally, CC-90005 (100 mg/kg; a single p.o.) significantly inhibits plasma and spleen IL-2 release by 51% and 54%, respectively[1]. CC-90005 demonstrates reasonable oral bioavailability (66% in rats and 46% in dogs) and Cmax (1.18 μM in rats and 1.2 μM in dogs) following oral administration (10 mg/kg in rats and 3 mg/kg in dogs)[1]. Following intravenous administration (2 mg/kg in rats and 1 mg/kg in dogs), CC-90005 exhibits a mean residence time of 0.52 h in rats and 2.0 h in dogs, clearance (CL) of 69.1 mL/min/kg in rats and 20.5 mL/min/kg in dogs, and volume of distribution at steady state (Vss) of 2.11 L/kg in rats and 2.44 L/kg in dogs[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | CC-90005 | CC90005 | CC 90005 |
| Inhibitors Related | PKN1/2-IN-1 | Forskolin | Darovasertib | Ellagic acid | α-Vitamin E | Ro-3306 | Staurosporine | Methyl-Hesperidin | Gondoic acid | Miltefosine | Fasudil hydrochloride | R59949 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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