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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>CC0651
CC0651
  • CC0651

CC0651 NEW

Price $1820 $2380 $3100
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2025-07-17

Product Details

Product Name: CC0651 CAS No.: 1319207-44-7
Supply Ability: 10g Release date: 2025/07/17

Product Introduction

Bioactivity

NameCC0651
DescriptionCC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme that potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM).
In vitroCC0651 functions by stabilizing a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site. It completely inhibits polyubiquitin chain assembly, reduces the formation of free triubiquitin, and minimally affects hCdc34 monoubiquitin production, with no impact on diubiquitin production [1]. CC0651 significantly impairs the initiation rate of ubiquitin chains on substrates by SCFCdc4, as indicated by the monoubiquitination of Sic1 by K0 ubiquitin. Interestingly, CC0651 enhances the formation of ubiquitin dimers and monoubiquitinated hCdc34, consistent with the accumulation of the hCdc34 conjugate in cells treated with its ester derivative. A quantitative SCF ubiquitination assay using a β-Catenin substrate peptide determined an IC50 value of 18±1 μM for CC0651 inhibition, aligning with concentrations effective in NMR and TR-FRET assays [2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 56 mg/mL (126.61 mM), Sonication is recommended.
Keywordsp27Kip1 ubiquitination | CC-0651 | CC0651 | CC 0651

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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