CCR2 antagonist 4 hydrochloride NEW
| Price | $52 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: CCR2 antagonist 4 hydrochloride | CAS No.: 1313730-14-1 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | CCR2 antagonist 4 hydrochloride |
| Description | CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |
| In vitro | Ile263 and Thr292 in CCR2 significantly contribute to the binding of CCR2 antagonist 4. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride. Additionally, Glu291 in TM7 substantially impacts the binding of the protonated CCR2 antagonist 4 hydrochloride and CCL2 [2]. |
| In vivo | In ApoE-deficient mice, CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Teijin compound 1 Hydrochloride | CCR2b | CCR-2 antagonist 4 hydrochloride | CCR2 antagonist 4 Hydrochloride |
| Inhibitors Related | AZD2098 | MLN-3897 TFA | Artemotil | CCR2 antagonist 5 | INCB-9471 | Maraviroc | BMS-817399 | Ancriviroc | Pirfenidone | Vercirnon | PNU-177864 | CCR6 antagonist 1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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