CCT241161 NEW
| Price | $139 | $343 | $490 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: CCT241161 | CAS No.: 1163719-91-2 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | CCT241161 |
| Description | CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It exhibits significant activity against BRAF and NRAS mutant melanomas and demonstrates anticancer cell proliferative effects [1]. |
| In vitro | CCT241161 demonstrated broad-spectrum efficacy across various concentrations and exposure times in inhibiting key cellular targets and pathways involved in melanoma and other cancers. At nanomolar to micromolar concentrations (ranging from 0.1 μM to 100 μM), and incubation times from 4 hours to 20 days, CCT241161 effectively inhibited MEK and ERK in WM266.4 cells, BRAF V600E in Ba/F3 cells, and maintained its inhibitory activity against A375 cells without inducing drug resistance over a 20-day period. Additionally, CCT241161 suppressed BRAF-inhibitor-resistant melanoma cells, demonstrated anti-proliferative activity in D04 cells, and inhibited MEK in NRAS mutant cells. Cell viability and proliferation assays, along with Western Blot analysis, confirmed the compound's effectiveness in not only inhibiting key signaling molecules like MEK, ERK, and SRC in various cell lines, including those resistant to BRAF inhibitors but also in suppressing cell growth in NRAS mutant and BRAF mutant cell lines, showcasing its potential as a versatile anticancer agent. |
| In vivo | CCT241161, administered at dosages of 10 and 20 mg/kg via oral gavage once daily for a period of seven days, effectively inhibits tumor growth in xenograft models of BRAF mutant A375, PLX4720-resistant A375, and NRAS mutant DO4 tumors in female nude mice aged 5 to 6 weeks without causing a reduction in body weight [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 75 mg/mL (138.47 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 7.5 mg/mL (13.85 mM), Suspension. 10% DMSO+90% Saline : < 7.5 mg/mL (13.85 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | Raf | CCT-241161 | CCT241161 | CCT 241161 |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Reprogramming Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | MAPK Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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