Product Details
| Product Name:
CCT251236 |
CAS No.:
1693731-40-6 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2025/12/22 |
Product Introduction
Bioactivity
| Name | CCT251236 |
| Description | CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1. |
| In vitro | CCT367766 (0-100 nM; 24 hours) inhibited 17-AAG-induced HSF1-mediated expression of heat shock proteins HSP72 and HSP27 in SK-OV-3 cells in a concentration-dependent manner; CCT367766 also blocked 17-AAG-induced HSPA1A mRNA in a dose-dependent manner; in addition, CCT367766 (0-100 nM; 24 hours) exhibited an ideal balance of in vitro properties while maintaining good cell viability, with pIC50=7.73±0.07 (IC50=19 nM) for inhibiting HSF1-mediated HSP72 induction; in SK-OV-3 cells, the free GI50 was 1.1 nM[1]. |
| In vivo | CCT367766 (oral; 20 mg/kg; 33 days) showed significant efficacy in mice, with a tumor growth inhibition (%TGI) of 70% based on final tumor volume.After 33 days, there was a 64% reduction in mean tumor weight compared to controls. In addition, the basicity and high volume of distribution of the compound was observed in tumors up to a concentration of 940 nM [1].CCT367766 (oral, 5 or 20 mg/kg) showed free Cav0-24h values of 2.0 nM and 1.2 nM, respectively, in tumor-free immune-competent BALB/c mice [1]; and, in a mouse model of human myeloma xenografts, the CCT251236 (20 mg/kg, po) inhibited the HSF1 pathway and exhibited antimyeloma efficacy in a human myeloma xenograft mouse model [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (144.76 mM), Sonication is recommended.
|
| Keywords | SK-OV-3 cells | HSP72 | HSF1 | CCT-251236 | CCT251236 | CCT 251236 |
| Inhibitors Related | Ethoxyquin | SNX0723 | Tamoxifen | SNX2112 | Ganetespib | Teprenone | Elesclomol | Rifabutin | Palmitic acid | Paeoniflorin | Tamoxifen Citrate | 17-AEP-GA |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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