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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>CCT251545
CCT251545
  • CCT251545

CCT251545 NEW

Price $35 $81 $129
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-06

Product Details

Product Name: CCT251545 CAS No.: 1661839-45-7
Purity: 98.29% Supply Ability: 10g
Release date: 2026/05/06

Product Introduction

Bioactivity

NameCCT251545
DescriptionCCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
In vitroCCT251545, a small-molecule inhibitor of the WNT pathway discovered through cell-based screening, is a potent and selective chemical probe for the human Mediator complex-associated protein kinases CDK8 and CDK19 with >100-fold selectivity over 291 other kinases.?X-ray crystallography demonstrates a type 1 binding mode involving insertion of the CDK8 C terminus into the ligand binding site.?In contrast to type II inhibitors of CDK8 and CDK19, CCT251545 displays potent cell-based activity.?We show that CCT251545 and close analogs alter WNT pathway-regulated gene expression and other on-target effects of modulating CDK8 and CDK19, including expression of genes regulated by STAT1.?Consistent with this, we find that phosphorylation of STAT1(SER727) is a biomarker of CDK8 kinase activity in vitro and in vivo[1].
In vivoIn vivo, CCT251545 with WNT-dependent tumors activity[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.37 mM), Sonication is recommended.
DMSO : 1 mg/mL (2.37 mM), Sonication is recommended.
Keywordsβcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | WNT, 7dF3 cells | Wnt | Inhibitor | inhibit | CCT-251545 | CCT251545 | CCT 251545 | beta-catenin | betacatenin | bcatenin
Inhibitors RelatedChlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin
Related Compound LibrariesAnti-Lung Cancer Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Prostate Cancer Compound Library | Anti-Fibrosis Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$35.00
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TargetMol Chemicals Inc.
2026-05-06

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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