Centanafadine NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Centanafadine | CAS No.: 924012-43-1 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Centanafadine |
| Description | Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter). |
| In vitro | Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines with human transporters, showing high affinity for NE (IC50: 6 nM) and DA (IC50: 38 nM) transporters, while exhibiting a lesser effect on the 5-HT transporter (IC50: 83 nM). |
| In vivo | In microdialysis studies, Centanafadine significantly increases NE and DA levels in the rat prefrontal cortex in vivo, with peak increases of 375% and 300%, respectively, primarily affecting NE, and elevates DA extracellular concentrations in the striatum to 400% of baseline. Centanafadine dose-dependently reduces immobility in the mouse tail suspension test of depression to 13% of control levels, without stimulating locomotor activity in adult rats at optimal doses, and inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternal) as neonates. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | human serotonin | human NE | human DA | EB1020 | EB 1020 | Centanafadine |
| Inhibitors Related | Dapoxetine hydrochloride | Hexamethonium Bromide | Octopamine hydrochloride | L-DOPA | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | Creatine | D-Mannitol | Oxolinic acid | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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