Factory Provide High Quality Ceritinib (LDK378) CAS 1032900-25-6 Powder

Introduction

Product Name : Ceritinib

Other name:LDK378;LDK378/LDK-378;5-Chloro-N2-[2-isopropoxy-5-Methyl-4-(4-piperidyl)phenyl]-N4-(2-isopropylsulfonylphenyl)pyriMidine-2,4-diaMine;

CAS No.: 1032900-25-6

Molecular Formula: C28H36ClN5O3S

Molecular Weight: 558.14

Specification:99%

Appearance: White powder or crystal 

Melting Point :173-175°C (rough estimate)

Boiling Point :720.7±70.0 °C(Predicted)

Density: 1.251±0.06 g/cm3(Predicted)

Storage :Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Ceritinib is a drug for the treatment of lung cancer. It is an ALK inhibitor. It was approved in April 2014 by the Food and Drug Administration for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) following treatment with crizotinib.

Function:
1.It is a tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK). It can promote the development of cancer cells by blocking the protein and inhibit the cells expressing EML4-ALK and NPM-ALK fusion protein.
2.Cerinib, a novel ALK inhibitor, is highly active in advanced patients.

Application:
1. 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.
2. Ceritinib LDK378 use for ALK-positive metastatic non-small cell lung cancer.