Cevimeline hydrochloride NEW
| Price | $59 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: Cevimeline hydrochloride | CAS No.: 107220-28-0 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | Cevimeline hydrochloride |
| Description | Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations. |
| In vitro | In digested parotid gland cells, Cevimeline hydrochloride (0.1-100 μM) induced a concentration-dependent increase in intracellular Ca2+ triggering exocytosis [1]. |
| In vivo | In male Wistar rats, intraperitoneal (i.p.) injection of Cevimeline hydrochloride (0.008-0.016 mg/kg) induces long-lasting salivation and increases parotid gland blood flow. Furthermore, Cevimeline hydrochloride inhibits water intake induced by Angiotensin II (AngII) [1][2][5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Soluble H2O : 40 mg/mL (169.66 mM), Sonication is recommended. |
| Keywords | Evoxac | Cevimeline Hydrochloride | Cevimeline hydrochloride |
| Inhibitors Related | Adiphenine hydrochloride | Uridine 5'-monophosphate disodium salt | Urethane | Hexamethonium Bromide | Ribavirin | Diethyltoluamide | Adenine | Mitotane | N,N-Dicyclohexylcarbodiimide | Dimethyl sulfoxide | Coumaran | Arecoline |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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