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Postion:Product Catalog >CGP37157
CGP37157
  • CGP37157

CGP37157 NEW

Price $45 $77 $155
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: CGP37157 CAS No.: 75450-34-9
Purity: 99.92% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameCGP37157
DescriptionCGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.
In vitroAdministration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity[2]. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons[3].
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (30.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 150 mg/mL (462.65 mM), Sonication is recommended.
10% DMSO+90% Corn oil : 10 mg/mL (30.84 mM), Solution.
10% DMSO+90% Saline : < 10 mg/mL (30.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (30.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
KeywordsNa+Exchanger | Na+/Ca2+ exchanger | Na+ Exchanger | Inhibitor | inhibit | CGP-37157 | CGP37157 | CGP 37157 | Ca2+Exchanger | Ca2+ Exchanger
Inhibitors RelatedORM-10103 | PPADS tetrasodium | ORM-10962 | SEA0400 | YM-244769 dihydrochloride | SM-6586 | YM-244769 | Terfenadine | SN 6 | FR183998 free base | KB-R7943 mesylate | Benzamil
Related Compound LibrariesMitochondrial Membrane Protein-Targeted Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Anhui Ruihan Technology Co., Ltd
2023-08-21

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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