CH-223191 NEW
| Price | $56 | $98 | $178 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: CH-223191 | CAS No.: 301326-22-7 |
| Purity: 99.37% | Supply Ability: 10g |
| Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | CH-223191 |
| Description | CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection. |
| In vitro | METHODS: HepG2 cells were treated with CH-223191 (0.1-10 μM) for 1 hour, and the protein levels were detected by Western Blot method. RESULTS: C-223191 reduces the expression of cytochrome P450 1A1 protein caused by TCDD. [1] |
| In vivo | METHODS: To study the preventive toxic effects of CH-223191 on 2,3,7,8-TCDD, CH-223191 (10 mg/kg) was intraperitoneally injected into male ICR mice once a day for 25 consecutive days. RESULTS: C-223191 inhibited the expression of liver cytochrome P450 1A1 and the intracellular fat content in hepatocytes, and reduced the AST and ALT activities in mice treated with TCDD. [1] |
| Storage | The compound is unstable in solution. Please use soon, Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 3.3 mg/mL (9.9 mM), Sonication is recommended. DMSO : 127 mg/mL (380.94 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (3 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | CH-223191 | CH223191 | ArylHydrocarbonReceptor | Aryl Hydrocarbon Receptor | AhR |
| Inhibitors Related | Nimodipine | Diosmin | Sudan IV | 2-Mercaptobenzothiazole | Benzyl butyl phthalate | 1-Hydroxypyrene | Skatole | Tryptamine hydrochloride | L-Kynurenine | Indole-3-carbinol | Leflunomide | Dibenzothiophene |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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