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Postion:Product Catalog >Catalyst and Auxiliary>polymer>Chitosan oligosaccharide
Chitosan oligosaccharide
  • Chitosan oligosaccharide

Chitosan oligosaccharide NEW

Price $48
Package 1g
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Chitosan oligosaccharide CAS No.: 148411-57-8
Supply Ability: 10g Release date: 2026/04/22

Product Introduction

Bioactivity

NameChitosan oligosaccharide
DescriptionChitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine that activates AMPK while inhibiting inflammatory signaling pathways, including NF-κB and MAPK.
In vitroActivation of AMPK and inhibition of inflammatory signaling pathways including NF-κB and MAPK pathways are recognized as major mechanisms responsible for several effects of Chitosan oligosaccharide (COS) including anti-inflammation, anti-cancer, and anti-diabetes. COS can interrupt cancer progression at multiple stages by modulating several signaling proteins/pathways including AMPK, NF-κB, mTOR, CD147, caspase-3, MMP-2, MMP-9, and VEGF. In vitro experiments have demonstrated that Chitosan oligosaccharide induced the death of several cancer cell types including ascites, bladder cancer, prostate cancer, lung cancer, liver cancer, leukemia, cervical cancer, and colorectal cancer. The values of IC50 of Chitosan oligosaccharide in inducing cytotoxicity are 25 μg/mL-50 μg/mL depending on types of cancer cells [1].
In vivoAdministering Chitosan oligosaccharide orally at a dose of 16 mg/kg/day effectively reduces the production of proinflammatory cytokines (IL-4, IL-13, and TNF-α) associated with allergic reactions in both lung tissue and the bronchoalveolar lavage fluid of mice. Additionally, this compound demonstrates an anti-inflammatory effect on lymphocyte activation in a rat model of autoimmune anterior uveitis, which is induced by immunization with bovine melanin-associated antigen [1]. Moreover, Chitosan oligosaccharide has shown to mitigate the effects of UV-induced damage in mouse skin, evident by preventing skin erythema, dryness, thickening, sagging, coarse wrinkles, and even the development of leathery appearance and slight flesh-colored lesions caused by 10 weeks of UV exposure. This contrasts significantly with the smoother, less wrinkled skin observed in the control group of hairless mice, as quantitatively supported by a significantly higher visual score in the model group (p<0.05) [2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL, Sonication is recommended.
H2O : 50 mg/mL, Sonication is recommended.
DMSO : 50 mg/mL, Sonication is recommended.
KeywordsInhibitor | inhibit | Chitosan oligosaccharide | AMPK | AMP-activated protein kinase
Inhibitors RelatedSucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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