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Postion:Product Catalog >Analytical Chemistry>Standard>Pharmaceutical Impurity Reference Standards>Chlorpheniramine Impurity E
Chlorpheniramine Impurity E
  • Chlorpheniramine Impurity E
  • Chlorpheniramine Impurity E
  • Chlorpheniramine Impurity E
  • Chlorpheniramine Impurity E
  • Chlorpheniramine Impurity E

Chlorpheniramine Impurity E NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-12-16

Product Details

Product Name: Chlorpheniramine Impurity E CAS No.: 120244-82-8
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/12/16
Molecular formula: C16H19ClN2O

Chlorpheniramine Impurity E

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


  • Product Information

  • Product Number: C046005

  • English Name: Chlorpheniramine Impurity E

  • English Alias: Chlorpheniramine N-Oxide;3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine oxide

  • CAS Number: 120244-82-8

  • Molecular Formula: C??H??ClN?O

  • Molecular Weight: 290.79

  • Advantages

  • As Impurity E of Chlorpheniramine (in N-oxide form), this compound has the following advantages:

  • Well-defined with distinct functional groups: Contains 3-(4-chlorophenyl)-3-(pyridin-2-yl)propane skeleton and N,N-dimethylamine oxide structure. Unlike chlorpheniramine (antihistamine with tertiary amine), its N-oxide (-N?(O?)(CH?)?) polarity, chlorine electronegativity, and pyridine aromaticity create significant differences, enabling precise differentiation via HPLC/ion-pair chromatography as a specific marker;

  • High stability and traceability: Rigid benzene/pyridine rings and stability of C-N bonds ensure neutral-to-weakly-alkaline stability. As a byproduct from chlorpheniramine storage or oxidative degradation, it directly reflects tertiary amine oxidation activity and environmental impact (oxygen, light), improving process tracing accuracy;

  • High detection sensitivity: Benzene-pyridine conjugation shows strong UV absorption (250-280nm), combined with m/z 291 [M+H]? enabling ppb-level analysis via LC-MS, compatible with antihistamine oxidative impurity systems.

  • Applications

  • Pharmaceutical quality control: Used as an impurity reference standard to quantify Chlorpheniramine Impurity E in APIs, ensuring residual oxidative degradation products meet quality standards;

  • Stability studies: Monitoring impurity levels under varying storage conditions (packaging, temperature) to assess oxidation trends and optimize storage to reduce N-oxide formation;

  • Degradation pathway analysis: Identifying tertiary amine oxidation as a key degradation route to guide process improvements (e.g., antioxidant addition).

  • Background Description

  • Chlorpheniramine is a first-generation antihistamine with a tertiary amine structure, acting by blocking histamine H1 receptors. Its tertiary amine group (-N(CH?)?) is prone to oxidation during storage (exposure to air, light, or metal catalysis), forming N-oxide derivatives like Chlorpheniramine Impurity E. Due to polarity differences affecting lipophilicity, its residues impact chlorpheniramine quality and efficacy, requiring strict control.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

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