Chlorpropamide NEW
| Price | $98 |
| Package | 10g |
| Supply Ability: | 10g |
| Update Time: | 2025-05-07 |
Product Details
| Product Name: Chlorpropamide | CAS No.: 94-20-2 |
| Purity: 99.01% | Supply Ability: 10g |
| Release date: 2025/05/07 |
Product Introduction
Bioactivity
| Name | Chlorpropamide |
| Description | Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. |
| Kinase Assay | Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter. |
| In vivo | At a concentration of 0.2 mM, chlorpropamide elevated the levels of fructose-2,6-bisphosphate (F-2,6-P2) in isolated hepatocytes from rats. The compound operates through a cyclic AMP-independent mechanism, enhancing insulin's inhibitory effect on glucagon-stimulated gluconeogenesis. Chlorpropamide significantly increased glucose metabolism and total lipid content, irrespective of insulin deficiency (30%) or presence (31%). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 51 mg/mL (184.29 mM), Sonication is recommended. DMSO : 55 mg/mL (198.74 mM), Sonication is recommended. |
| Keywords | Sodium potassium pump | Na+/K+ ATPase | Inhibitor | inhibit | Chlorpropamide | ABCC8 |
| Inhibitors Related | Tirofiban hydrochloride monohydrate | Sodium oleate | Vismodegib | Vigabatrin | trans-Aconitic acid | Phlorizin | Probucol | Revaprazan hydrochloride | Oleic acid | Acridone | Esomeprazole Sodium | Trichlormethiazide |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Approved Drug Library | Membrane Protein-targeted Compound Library | Anti-Diabetic Compound Library | Drug Repurposing Compound Library | Drug-Fragment Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Metabolism Disease Compound Library | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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