Cimetidine hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Cimetidine hydrochloride | CAS No.: 70059-30-2 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Cimetidine hydrochloride |
| Description | Cimetidine (SKF-92334) hydrochloride is an orally active inverse histamine H2 receptor antagonist with a Ki of 0.6 μM, demonstrating anti-cancer and anti-inflammatory activity, and is a gastric acid reducer useful in the research of duodenal and gastric ulcers [1] [2] [5]. |
| In vitro | Cimetidine (SKF-92334) hydrochloride, distinguished as a partial H2R agonist, exhibits a unique pharmacological profile compared to ranitidine and famotidine, which may underlie its anticancer effects on gastrointestinal malignancies [1]. In ovarian cancer cells expressing high OCT2 mRNA levels (IGROV-1 cells), cimetidine hydrochloride does not affect cisplatin's uptake or cytotoxicity [3]. Additionally, it does not influence the proliferation, survival, migration, or invasion of 3LL cells. However, cimetidine hydrochloride can counteract MDSC-mediated T-cell suppression and enhance IFN-γ production [4]. Its mechanism includes the suppression of NCAM gene expression through inhibiting NF-kappaB nuclear translocation, a key activator of NCAM [5]. |
| In vivo | Cimetidine (SKF-92334) hydrochloride effectively diminishes the accumulation of CD11b(+)Gr-1(+) myeloid derived-suppressive cells (MDSC) in the spleen, blood, and tumor tissues of mice with tumors [4]. Additionally, this compound positively influences periodontal disease in rats by lowering the RANKL/OPG ratio in gingival connective tissue and mitigating alveolar bone resorption [6]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Neomycin sulfate | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | Alginic acid | BES |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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