Cl-amidine TFA NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: Cl-amidine TFA | CAS No.: 1043444-18-3 |
| Supply Ability: 10g | Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | Cl-amidine TFA |
| Description | Cl-amidine TFA is an orally active PAD inhibitor with IC?? values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3 and PAD4, respectively. This compound can induce cancer cell apoptosis, and also upregulate the expression of miR-16 (miRNA-16, microRNA-16), thereby triggering cell cycle arrest. In addition, Cl-amidine TFA can block the citrullination of histone 3 and the formation of neutrophil extracellular traps, effectively improving the survival rate of mice with sepsis. |
| In vitro | Cl-amidine TFA is a bioavailable haloacetamidine-based compound that inhibits all active PAD isozymes with comparable potency, with an inactivation efficiency constant of 13,000 M?1·min?1 for PAD4[1]. When cells are treated with Cl-amidine TFA at concentrations of 0, 5, 10, 15, 20, 25 and 50 μg/mL for 24 hours, it induces apoptosis in TK6 lymphoblastoid cells and HT29 colon cancer cells in a dose-dependent manner; notably, the HT29 colon cancer cell line exhibits relative resistance to apoptosis induced by Cl-amidine[2]. Cl-amidine TFA achieves irreversible inactivation of PADs by covalently modifying the cysteine residue in the PAD active site that is involved in catalytic activity[4]. |
| In vivo | At a dose of 75 mg/kg administered intraperitoneally once daily, Cl-amidine TFA exerts inhibitory and therapeutic effects on dextran sulfate sodium-induced colitis in mice[2]. When administered by oral gavage at doses of 5, 25 and 75 mg/kg once daily, Cl-amidine TFA also significantly reduces the histological scores in a dose-dependent manner[2]. |
| Storage | store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PAD4 | Cl-amidine TFA | Clamidine TFA | Cl amidine TFA |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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