CL097 NEW
| Price | $32 | $73 | $138 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-27 |
Product Details
| Product Name: CL097 | CAS No.: 1026249-18-2 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2026/07/27 |
Product Introduction
Bioactivity
| Name | CL097 |
| Description | CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. |
| In vitro | CL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils[1]. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells[3]. |
| In vivo | in NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (～25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 10 mg/mL (41.27 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (13.62 mM), Sonication is recommended. DMSO : 100 mg/mL (412.75 mM), Sonication is recommended. |
| Keywords | Toll-like Receptor (TLR) | TLR8 | TLR7 | ReactiveOxygenSpecies | Reactive Oxygen Species | Peptide | Oligonucleotide | modulators | Inhibitor | inhibit | Immunological | Heterocycle | CL-097 | CL 097 |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Imeglimin hydrochloride | Hydroxychloroquine | Triphenyl phosphate | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | Zinc chloride | Dimethyl phthalate | 6-PPD |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Breast Cancer Compound Library | Antioxidant Compound Library | Mitochondria-Targeted Compound Library | Lipid Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Oxidation-Reduction Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1450.00 |
VIP3Y
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TargetMol Chemicals Inc.
|
2026-07-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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