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Postion:Product Catalog >CL097
CL097
  • CL097

CL097 NEW

Price $32 $73 $138
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: CL097 CAS No.: 1026249-18-2
Purity: 99.88% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameCL097
DescriptionCL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
In vitroCL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils[1]. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells[3].
In vivoin NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (~25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : 10 mg/mL (41.27 mM), Solution.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (13.62 mM), Sonication is recommended.
DMSO : 100 mg/mL (412.75 mM), Sonication is recommended.
KeywordsToll-like Receptor (TLR) | TLR8 | TLR7 | ReactiveOxygenSpecies | Reactive Oxygen Species | Peptide | Oligonucleotide | modulators | Inhibitor | inhibit | Immunological | Heterocycle | CL-097 | CL 097
Inhibitors RelatedEthoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Imeglimin hydrochloride | Hydroxychloroquine | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | L-Ascorbic acid sodium salt | Dimethyl phthalate
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | Antioxidant Compound Library | Anti-Prostate Cancer Compound Library | Mitochondria-Targeted Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Oxidation-Reduction Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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