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Postion:Product Catalog >CLP257
CLP257
  • CLP257

CLP257 NEW

Price $38 $54 $89
Package 1mg 2mg 5mg
Supply Ability: 10g
Update Time: 2026-04-20

Product Details

Product Name: CLP257 CAS No.: 1181081-71-9
Purity: 99.50% Supply Ability: 10g
Release date: 2026/04/20

Product Introduction

Bioactivity

NameCLP257
DescriptionCLP257 is a selective K+-Cl? cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl? transport in neurons with diminished KCC2 activity.
In vitroOocyte pre-incubation with CLP257 (200 nM) increases KCC2 transport activity by 61%. However, it causes no change in other CCCs. There is no change in [Cl?]i in HEK293-cl cells when incubated with CLP257. CLP257 (50 μM) provokes < 0.2% of the effect of 5 μM muscimol in CHO cells transduced with recombinant α1β2γ2 GABAA receptors. Dose-dependent antagonism is also observed between CLP257 and the recently characterized KCC2 antagonist VU024055119 [1].
In vivoCLP257 (100?mg/kg; i.p.; adult male rats) treatment causes an obvious increase in mechanical sensitivity [2].
StoragePowder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.25 mM), Sonication is recommended.
DMSO : 17.86 mg/mL (58.11 mM), Sonication is recommended.
Keywordssensitivity | PotassiumChannel | Potassium Channel | post-translationally | plasma | neuropathic | membrane | mechanical | KcsA | KCC2 | Inhibitor | inhibit | hypersensitivity | CLP-257 | CLP257 | CLP 257 | antihyperalgesic
Inhibitors RelatedMinoxidil sulfate | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | 2,2,2-Trichloroethanol | Chlorzoxazone | Taurocholic acid sodium salt hydrate | Indapamide

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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