Product Details
| Product Name:
CMLD012612 |
CAS No.:
2368900-35-8 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | CMLD012612 |
| Description | CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM). |
| In vitro | The primary action of CMLD012612 hinges on its interaction with eIF4A1, as demonstrated by eIF4A1em1jp cells exhibiting at least a 10-fold increased resistance compared to the original NIH/3T3 cells. This resistance is diminished at higher concentrations of CMLD012612, possibly because of the presence of wild-type eIF4A2 in the eIF4A1em1jp cells. |
| In vivo | When administered to mice bearing myr-Akt/Em-Myc lymphomas, CMLD012612 (0.2 mg/kg; i.p.; daily; for 5 days; female C57BL/6 mice) treatment effectively synergizes with Doxorubicin, leading to complete tumor loss. CMLD012612 (0.5 mg/kg; i.p.; for 3 hours; female C57BL/6 mice) treatment effectively suppresses liver polysomes 3 hours after injection. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | eIF4A | CMLD-012612 | CMLD012612 | CMLD 012612 |
| Inhibitors Related | 2-Ethoxybenzamide | GCN2-IN-1 | GSK2606414 | DNL343 | Sinapaldehyde | Milnacipran hydrochloride | 1,2,4-Trihydroxybenzene | 8-Gingerol | PERK-IN-4 | ATPγS tetralithium salt | Daraxonrasib | 4EGI-1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
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$1980.00
|
VIP2Y
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TargetMol Chemicals Inc.
|
2025-08-22 |
United States