CMP-5 hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: CMP-5 hydrochloride | CAS No.: 1030021-40-9 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | CMP-5 hydrochloride |
| Description | CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. |
| In vitro | CMP-5 (0-100 μM; 24-72 hours) exhibits selective toxicity towards lymphoma cells, while showing limited toxicity to normal resting B lymphocytes, even with extended incubation. CMP-5 (0-40 μM; 24 hours) preferentially inhibits the proliferation of human Th1 cells over Th2 cells (43% vs. 9% inhibition, respectively), with IC50 values of 26.9 μM for Th1 cells and 31.6 μM for Th2 cells, indicating differential sensitivity to PRMT5 inhibition. CMP-5 (40 μM; 24 hours) reduces p-BTK and pY(416)SRC expression in 60A cells compared to the DMSO-treated group. Additionally, CMP-5 (25 μM; 24 hours) alone inhibits mouse Th1 cell proliferation by 91%; however, the addition of varying doses of IL-2 enhances proliferation, peaking at 5 ng/ml [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | mTh2 cells | mTh1 cells | hTh2 cells | hTh1 cells | CMP-5 Hydrochloride | CMP5 Hydrochloride | CMP5 hydrochloride | CMP 5 hydrochloride | CMP 5 Hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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