CNS-5161 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-07-31 |
Product Details
| Product Name: CNS-5161 | CAS No.: 160754-76-7 |
| Supply Ability: 10g | Release date: 2026/07/31 |
Product Introduction
Bioactivity
| Name | CNS-5161 |
| Description | CNS-5161 is a selective, non-competitive NMDA receptor antagonist that is able to displace [3H] MK-801 binding with a Ki of 1.8 nm. CNS-5161 inhibits NMDA receptor-mediated excitatory neurotransmission in both in vitro and in vivo experiments, thereby facilitating the study of neuroprotective mechanisms and related signaling pathways. CNS-5161 is commonly used in neuroscience research to assess excitotoxicity and neuronal survival in model systems, and can be employed in studies of the mechanisms underlying central nervous system disorders. |
| In vitro | Method: [3H]CNS-5161 (0.1–2.5 nM) was incubated with brain cell membranes. Control groups (± glutamate/glycine) were established, and 100 μM MK-801 was used to assess non-specific binding. Kd and Bmax were determined using Scatchard analysis. Results: [3H] CNS-5161 exhibits monovalent, high-affinity binding; at 37°C, Kd = 3.1 nM and Bmax = 3.2 pmol/mg protein. [2] |
| In vivo | Methods: Rats were administered 1 mCi/kg of [3H] CNS-5161 via the tail vein, pretreated with saline, NMDA, MK-801, or NMDA+MK-801. Tissues were harvested at 5–120 min to measure radioactivity, and the brain region/cerebellum ratio was calculated. Results: The drug rapidly entered the brain, with brain uptake reaching 1.46% ID at 5 min; brain distribution in normal rats: hippocampus and cortex > thalamus > striatum > cerebellum, with a cortex/cerebellum ratio of 1.4; NMDA pretreatment increased the hippocampus/cerebellum ratio to 1.6–1.9, and MK-801 blocked this increase. [2] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | CNS-5161 | CNS 5161 |
| Inhibitors Related | Indole-2-carboxylic acid | Mephenesin | Quinolinic acid | Urethane | Kynurenic acid | Halothane | D-Serine | Bupivacaine hydrochloride monohydrate | Memantine hydrochloride | O-Phospho-L-serine | Procaine hydrochloride | UBP551 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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