Colistin Introduction

Definition:
Colistin is a polymyxin antibiotic derived from Bacillus colistinus. It is effective against Gram-negative bacteria, particularly multidrug-resistant strains.

Function:
Colistin disrupts bacterial cell membranes, leading to cell death. It is used as a last-resort antibiotic for treating infections caused by resistant bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.

Application:
Colistin is used in human and veterinary medicine to treat severe bacterial infections. It is available in intravenous, inhalation, and oral forms, as well as feed additives for livestock to prevent bacterial diseases.