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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>Concanamycin A (1 mg/ml solution in acetonitrile)
Concanamycin A  (1 mg/ml solution in acetonitrile)
  • Concanamycin A  (1 mg/ml solution in acetonitrile)

Concanamycin A (1 mg/ml solution in acetonitrile) NEW

Price $293
Package 100μg
Supply Ability: 10g
Update Time: 2026-05-26

Product Details

Product Name: Concanamycin A (1 mg/ml solution in acetonitrile) CAS No.: 80890-47-7
Supply Ability: 10g Release date: 2026/05/26

Product Introduction

Bioactivity

NameConcanamycin A (1 mg/ml solution in acetonitrile)
DescriptionConcanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.
In vitroIn CD8+ cytotoxic T lymphocytes (CTLs), Concanamycin A (100 nM; 0, 4, 8, 12, 16, 20 hours) induced rapid cell death instead of apoptosis at 20 hours, without observed nuclear condensation[2].
In vivoIn wild type mice, Concanamycin A (15 mg/kg; intravenous injection at 0, 10, or 24 hours prior to sacrifice) resulted in significant liver injury, as demonstrated by increased serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and elevated expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 and 24 hours following administration[5].
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 8 mg/mL (9.24 mM), Sonication is recommended.
Methanol : 8 mg/mL (9.24 mM), Sonication and heating are recommended.
KeywordsVacuolar type H+-ATPase | HIVProtease | HIV Protease | HIV | Folimycin | Concanamycin A
Inhibitors RelatedNeomycin sulfate | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Lamivudine | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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