Product Details
| Product Name:
COR659 |
CAS No.:
544450-68-2 |
| Purity:
99.75% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | COR659 |
| Description | COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. |
| In vitro | COR659 exerts its effects through a composite mechanism, including positive allosteric modulation of the GABAB receptor and action at the cannabinoid CB1 receptor [3]. |
| In vivo | COR659 (0, 2.5, 5, and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1]. However, COR659 suppresses lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. |
| Storage | Keep away from direct sunlight,Keep away from moisture,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.92 mM), Sonication is recommended.
DMSO : 33.33 mg/mL (98.66 mM), Sonication is recommended.
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| Keywords | γ-Aminobutyric acid Receptor | sucrose | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAB | GABA Receptor | COR-659 | COR659 | COR 659 | chocolate | CB1 | CannabinoidReceptor | Cannabinoid Receptor | alcohol |
| Inhibitors Related | DL-Menthol | Valproic acid sodium salt | β-Caryophyllene | p-Hydroxybenzaldehyde | Urethane | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | 2,3-Butanediol | (-)-α-Pinene | Dihydromyricetin | Methionine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Neuroprotective Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States