Corynoxine B NEW
| Price | $93 | $228 |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: Corynoxine B | CAS No.: 17391-18-3 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | Corynoxine B |
| Description | Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956) |
| In vitro | 25-100 μM Corynoxine B, treated for 2 h, ameliorated autophagy dysregulation and neurotoxicity in Mn-induced SH-SY5Y human neuroblastoma cells. [1] In PC12 cells, Corynoxine B upregulated BECN1 protein expression and restored autophagy inhibition induced by SNCA/α-synuclein (α-syn) overexpression. [2] |
| In vivo | In a mouse model of Parkinson's disease, intraperitoneal injection of 5-20 mg/kg Corynoxine B promotes autophagic clearance of α-synuclein (α-syn) by targeting HMGB1/2. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (8.58 mM), Sonication is recommended. DMSO : 80 mg/mL (208.08 mM), Sonication is recommended. |
| Keywords | α-synuclein | Corynoxine B | Beclin1 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, USA
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