Product Details
| Product Name:
CP-547632 TFA |
CAS No.:
2805804-54-8 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | CP-547632 TFA |
| Description | CP-547632 TFA is an orally active, ATP-competitive inhibitor that potently targets VEGFR-2 and FGF kinases with IC50 values of 11 nM and 9 nM, respectively. It demonstrates selectivity for VEGFR-2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs), exhibiting antitumor efficacy [1]. |
| In vitro | CP-547632 TFA (1-1000 nM; 1 hour) inhibits VEGF-induced VEGFR-2 phosphorylation in a dose-dependent manner, with an IC50 of 6 nM [1]. |
| In vivo | CP-547632 TFA, when administered orally in doses ranging from 6.25 to 100 mg/kg/day over a period of 10-24 days, results in a dose-dependent suppression of tumor growth in Colo-205, DLD-1, and MDA-MB-231 xenografts [1]. A single oral dose of 50 mg/kg produces plasma concentrations exceeding 500 ng/ml for a duration of up to 12 hours [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Ribociclib | Amlexanox | Sorafenib | Ferulic Acid | glycine | Nintedanib esylate | Regorafenib | Chloramphenicol | Formononetin | Thymoquinone | Lenvatinib | Pazopanib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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