Product Details
| Product Name:
CX717 |
CAS No.:
867276-98-0 |
| Purity:
99.81% |
Supply Ability:
10g |
| Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | CX717 |
| Description | CX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research [1] [2]. |
| In vivo | CX 717 (CX717; 20 mg/kg) exhibits a rapid (30 min) but short-lasting (up to 24 h) antidepressant-like effect in the forced swim test. It swiftly increases brain-derived neurotrophic factor (BDNF) within 1 hour and sustains elevated p11 levels for up to 6 hours [2]. When infused intra-cortically at 85 mM, CX 717 enhances the efflux of noradrenaline, dopamine, and serotonin without altering glutamate levels [2]. Male Sprague-Dawley rats (280-350 g) received a dosage of 20 mg/kg (at 1 mL/kg) via intraperitoneal injection. Results indicated that CX 717 provoked antidepressant-like effects without changing extracellular noradrenaline (NA), dopamine (DA), serotonin (5-HT), and glutamate levels in the medial prefrontal cortex (mPFC) [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.58 mM), Sonication is recommended.
DMSO : 45 mg/mL (192.94 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | CX-717 | CX717 | CX 717 | AMPA |
| Inhibitors Related | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | Kynurenic acid | L-Phenylalanine | Indole-2-carboxylic acid | L-Glutamine | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States