Mainly used in craniocerebral trauma and brain surgery after metabolic disorders, consciousness disorders, paralysis tremor, neurological deafness and tinnitus, as well as sleeping pills poisoning. In addition, it also has a good effect on Parkinson's syndrome and cerebral thrombus paraplegia.

Clinical application

CYTIDINE 5'-DIPHOSPHOCH is a single nucleotide composed of nucleic acid, cytosine, pyrophosphate and choline, which is mainly used in clinical treatment of a variety of neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis and so on. Studies have also shown that citicoline can increase the brain's uptake of dopamine and glutamate, thereby improving cognitive performance. Ciphocholine can also reduce the release of free fatty acids and restore the activity of mitochondrial ATPase and cell membrane Na+/K+ ATPase, thus alleviating brain injury. However, the pathophysiological mechanisms of neurodegenerative diseases are complex and involve cholinergic deficiency, glutamate excitotoxicity, neuroinflammation, immune dysregulation, decreased glucose metabolism, and breakdown of the blood-brain barrier.

Function and mechanism of action

CYTIDINE 5'-DIPHOSPHOCH can stabilize the cell membrane by stimulating S-adenosine-L-methionine, increase the dendrite complexity and spinous process density of motor neuron structure, improve the plasticity of nerve in the non-damaged area, and promote functional recovery. By up-regulating choline cytidylyl transferase phosphate (CCT), the level of water-soluble lecithin phosphate can be reduced, and the activity of secretory phospholipase A2(PLA2) can be inhibited, or the activation of PLA2 can be inhibited by inhibiting TNF-a/IL-1b, so as to reduce the loss of phospholipid, thereby increasing the synthesis of phospholipid and repairing nerve cell membrane. It can also increase the expression of anti-apoptotic factors such as Bcl-2 and inhibit glutamate release to reduce cytotoxicity. It can promote the rapid repair of damaged cell surface and mitochondrial membrane, maintain cell tightness and biological function, and reduce free fatty acid release, thus reducing the production of toxic oxygenated metabolites and free radicals; It can increase vasopressin and plasma adrenotropin levels and stimulate the release of growth hormone, thyrotropin and luteinizing hormone.

Application:

1 It is used for consciousness disturbance after acute craniocerebral trauma and brain surgery. Cerebral thrombosis, multiple cerebral embolism, palsy tremor, sequela of stroke, cerebral arteriosclerosis caused by insufficient cerebral blood supply, hypnotic drugs and carbon monoxide poisoning and various organic encephalopathy.

2 It is a precursor of ovophosphate biosynthesis and can promote lecithin biosynthesis. The product can promote the recovery of brain function and awakening. It is suitable for brain trauma, stroke sequelae and other disorders of consciousness, but also for acute injury of the central nervous system caused by consciousness disorders.

3 It is used to treat acute craniocerebral trauma and consciousness disorder after brain surgery.