Dalbavancin hydrochloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Dalbavancin hydrochloride | CAS No.: 2227366-51-8 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Dalbavancin hydrochloride |
| Description | Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semi-synthetic lipopeptide antibiotic that inhibits bacterial cell wall synthesis and exhibits potent bactericidal activity against Gram-positive bacteria. The MIC90 values of dalbavancin hydrochloride against Staphylococcus aureus and Bacillus anthracis are 0.06 μg/mL and 0.25 μg/mL, respectively. |
| In vitro | Methods: Thirty strains of B. anthracis were selected and incubated with Dalbavancin hydrochloride at concentrations ranging from 0.03 to 64 μg/ml for 18–24 hours; the MIC was determined using the microdilution broth method. Results: The MIC range for Dalbavancin hydrochloride was ≤0.03–0.5 μg/ml; MIC?? = 0.06 μg/ml; MIC?? = 0.25 μg/ml.[1] |
| In vivo | Methods: To investigate the efficacy of Dalbavancin hydrochloride, female BALB/c mice were exposed to an aerosol challenge with Bacillus anthracis strain Ames. Twenty-four hours after infection, intraperitoneal injections of Dalbavancin hydrochloride (15–120 mg/kg) were administered daily for 14 days, and mouse survival rates were assessed 42 days later. Results: The survival rate of mice in the Dalbavancin hydrochloride treatment group was 80–100%. [1] Methods: To investigate the pharmacokinetics of repeated doses of Dalbavancin hydrochloride, SD rats were used. Dalbavancin hydrochloride (40 mg/kg) was administered intravenously once daily for 28 consecutive days. Blood samples were collected at the same time points as for the single-dose study following the final administration. Results: Compared with Day 1, the AUC(0–∞) on Day 28 increased 2–6-fold, indicating accumulation of Dalbavancin hydrochloride. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (107.92 mM), Sonication is recommended. H2O : 40 mg/mL (21.58 mM), Sonication is recommended. |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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