Description：Dapoxetine, chemically named (S)-(+)-N,N-dimethyl-3-(naphthyl-1-oxy)-1-amphetamine, is a new type of 5-hydroxytryptamine reuptake inhibitor. It is a water-soluble white or off-white powder. Its chemical structure is similar to the antidepressant fluoxetine. It is the only 5-hydroxytryptamine reuptake inhibitor that does not contain halogen atoms. The central neurotransmitters 5-hydroxytryptamine (5-HT) and dopamine and their receptors play an important role in regulating ejaculation. Dapoxetine can effectively inhibit 5-HT reuptake by inhibiting 5-HT transporters, increase 5-HT concentration in the synaptic cleft, activate 5-HT2C and 5-HT1A receptors on the postsynaptic membrane, and play a role in delaying ejaculation, thereby effectively controlling the symptoms of premature ejaculation in men. Compared with other 5-hydroxytryptamine reuptake inhibitors, dapoxetine has the advantages of good efficacy, short half-life, and fewer side effects.