Darifenacin NEW
| Price | $56 | $89 | $163 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Darifenacin | CAS No.: 133099-04-4 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Darifenacin |
| Description | Darifenacin (UK-88525) is a muscarinic receptor M3 antagonist with anticonvulsant activity and can be used to study urinary incontinence and overactive bladder. |
| In vitro | Darifenacin increased the accumulation of R123 (P-gp probe) in a concentration-dependent manner in MDCK cells. [1] Darifenacin stimulated ATPase activity in P-gp membranes in a concentration-dependent manner with an estimated ED50 = 1.6 μM. [1] 100 nM Darifenacin showed higher permeability in the basolateral to apical direction, leading to an exocytosis ratio of ~2.6 in BBMEC monolayer cells. [1] |
| In vivo | Darifenacin dose-dependently inhibited volume-induced bladder contraction amplitude (VIBCAMP), with 283.3 nmol/kg Darifenacin producing a 35% inhibition, with a maximum inhibition of approximately 50-55%. [2] Intravenous injection of 0.1 mg/kg Darifenacin in female Sprague-Dawley rats reduced bladder afferent activity in Aδ and C fibers, where the reduction in afferent spikes may be more pronounced in C fibers than in Aδ fibers. [3] |
| Storage | Store at low temperature,Keep away from direct sunlight Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (187.55 mM), Sonication is recommended. 10% DMSO+90% Saline : 8 mg/mL (18.76 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.74 mM), Sonication is recommended. |
| Keywords | mAChR |
| Inhibitors Related | Aceglutamide | Hyaluronic acid | Urethane | Fumaric acid | Adenine | Ethyl linoleate | D-Psicose | Mitotane | Methyl eugenol | N,N-Dicyclohexylcarbodiimide | Arecoline | 2,3-Butanediol |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Toxic Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Human Metabolite Library | Anti-Cancer Drug Library | MAPK Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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