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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>Delamanid
Delamanid
  • Delamanid

Delamanid NEW

Price $64 $126 $225
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: Delamanid CAS No.: 681492-22-8
Purity: 99.98% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameDelamanid
DescriptionDelamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall.
Kinase AssayIn a 200 μL reaction volume, 1 μM TEM-1 is incubated with and without 5 μM Avibactam for 5 min at 37°C and subjected to two ultrafiltration cartridge (UFC) steps to remove excess inhibitor (Ultrafree-0.5 with Biomax membrane, 5-kDa cutoff). Centrifugation at 10,600× g for 8 min is performed at 4°C. After each ultrafiltration step, 20 μL retentate is diluted with 180 μL assay buffer to restore the original enzyme concentration. After two UFC treatments, the amount of free Avibactam is quantified by LC/MS/MS and found to be <5% of the original concentration. Loss of protein during UFC is assessed by measuring TEM-1 activity (on 4,000-fold dilution) in the acyl-enzyme sample compare with a non-UFC-treated enzyme, and loss is found to be <5%[1].
In vitroIn vitro: inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.[1] In in-vitro studies, delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis.[2] Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration.
In vivoIn vivo: Twice-daily oral dosing of delamanid at 30 mg kg-1 for 5 days resulted in sterile cures in a mouse model of VL. [4]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (18.71 mM), Suspension.
10% DMSO+90% Saline : < 10 mg/mL (18.71 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 135 mg/mL (252.58 mM), Sonication is recommended.
KeywordsOPC67683 | OPC 67683 | Inhibitor | inhibit | Delamanid | Bacterial | Anti-infection | Antiinfection | Antibiotic
Inhibitors RelatedNeomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES
Related Compound LibrariesBioactive Compound Library | Approved Drug Library | ReFRAME Related Library | EMA Approved Drug Library | Antibiotics Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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