Desisobutyryl-ciclesonide NEW
| Price | $68 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Desisobutyryl-ciclesonide | CAS No.: 161115-59-9 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Desisobutyryl-ciclesonide |
| Description | Desisobutyryl-ciclesonide has an affinity for glucocorticoid receptors. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. |
| In vitro | Ciclesonide is an inhaled glucocorticoid with little affinity for glucocorticoid receptors. When converted into an active metabolite Desisobutyryl-ciclesonide, it is very effective in down-regulating the proinflammatory activity of airway parenchymal cells in vitro. 0.3-3.0μMCiclesonide and Desisobutyryl-Ciclesonide dose-dependently inhibited the proliferation of peripheral blood mononuclear cells to Candida albicans, but Desisobutyryl-Ciclesonide had a higher inhibitory effect. Significant proliferation of PhlP5 was observed only in cultures of ectopic subjects: effective downregulation has been detected at 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (at 3 μM Ciclesonide and 0.03 μM Desisobutyryl-ciclesonide Completely suppressed). 3μM Ciclesonide and Desisobutyryl-ciclesonide reduced the proportion of PhlP5-specific T cell embryonic cell proliferation and interleukin 4 producing cells. In PBMC cultures of atopic patients, both Csonide (CIC) and desisobutyryl-Crossonide (des-CIC) induced dose-dependent down-regulation of PhlP5-induced proliferation. At 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (p <0.001, each comparison), the effect is already significant (an earlier complete inhibition was observed at 3 μMCiclesonide and 0.03 μMDesisobutyryl-Ciclesonide. At 0.003 μM ( p<0.05), 0.03μM (p<0.001) and 0.3μM (p<0.05), the inhibitory activity of desisobutyryl-ciclesonide on PhlP5-induced PBMC proliferation was higher than that of Ciclesonide. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (106.25 mM), Sonication is recommended. |
| Keywords | Desisobutyryl ciclesonide | Desisobutyrylciclesonide | Desisobutyryl-ciclesonide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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