Product Details
| Product Name:
Dexloxiglumide |
CAS No.:
119817-90-2 |
| Purity:
99.78% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Dexloxiglumide |
| Description | Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist and the pharmacologically active enantiomer of Loxiglumide, effectively inhibiting smooth muscle contractions induced by cholecystokinin-octapeptide (CCK-8), while displaying moderate, polarized, concentration-dependent, and pH-dependent Caco-2 permeability and increasing uptake of the MRP1 substrate fluorescein. Dexloxiglumide supports the mechanistic studies of gastrointestinal disorders and tumor-related smooth muscle and transporter biology. |
| In vitro | In ex vivo studies utilizing human isolated gallbladder, Dexloxiglumide stimulated P-gp ATPase activity at concentrations > 17.3 μM, increased fluorescein uptake by 4-fold at 433 μM indicating MRP1 inhibition [1]. |
| In vivo | In rat models, intravenous administration of Dexloxiglumide dose-dependently inhibited the delay in gastric emptying induced by CCK-8, with an ID50 of 1.14 mg/kg. The compound demonstrated selectivity for the CCK1 receptor, as it did not affect pentagastrin-induced acid secretion, a process mediated by CCK2 (CCK-B) receptors, even at doses that fully blocked CCK1-mediated motility effects [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (86.7 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 2.5 mg/mL (5.42 mM), Sonication is recommended.
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| Keywords | Dexloxiglumide |
| Inhibitors Related | PHA-767491 | GV-150013X | CCKBR agonist-2 | (Iso)-FK-480 | Itriglumide | Caerulein, desulfated | GV150013 | Lintitript | N-Cbz-DL-tryptophan | A-65186 | Pranazepide | Spiroglumide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States